Strict Standards: Non-static method t3lib_extMgm::typo3_loadExtensions() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/config_default.php on line 390

Strict Standards: Non-static method t3lib_div::shortMD5() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_extmgm.php on line 935

Strict Standards: Non-static method t3lib_extMgm::isCacheFilesAvailable() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_extmgm.php on line 939

Strict Standards: Non-static method t3lib_extMgm::extPath() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 66

Strict Standards: Non-static method t3lib_extMgm::addService() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 69

Strict Standards: Non-static method t3lib_div::isFirstPartOfStr() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_extmgm.php on line 486

Strict Standards: Non-static method t3lib_div::isFirstPartOfStr() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_extmgm.php on line 487

Strict Standards: Non-static method t3lib_div::trimExplode() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_extmgm.php on line 531

Strict Standards: Non-static method t3lib_extMgm::extPath() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 83

Strict Standards: Non-static method t3lib_extMgm::extPath() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 102

Strict Standards: Non-static method t3lib_extMgm::extPath() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 156

Strict Standards: Non-static method t3lib_extMgm::addPageTSConfig() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 186

Strict Standards: Non-static method t3lib_extMgm::addPageTSConfig() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 189

Strict Standards: Non-static method t3lib_extMgm::addUserTSConfig() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 197

Strict Standards: Non-static method t3lib_extMgm::isLoaded() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 200

Strict Standards: Non-static method t3lib_extMgm::addPageTSConfig() should not be called statically in /homepages/u23225/typo3conf/temp_CACHED_ps414d_ext_localconf.php on line 257

Strict Standards: Non-static method t3lib_extMgm::isLoaded() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 96

Strict Standards: Non-static method t3lib_div::makeInstance() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 103

Strict Standards: Non-static method t3lib_div::clientInfo() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 106

Strict Standards: Non-static method t3lib_div::getIndpEnv() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3193

Strict Standards: Non-static method t3lib_div::int_from_ver() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 113

Strict Standards: Non-static method t3lib_div::addSlashesOnArray() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 118

Strict Standards: Non-static method t3lib_div::addSlashesOnArray() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 119

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 129

Strict Standards: Non-static method t3lib_extMgm::extPath() should not be called statically in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 88

Strict Standards: Non-static method t3lib_div::makeInstanceClassName() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 154

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 157

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 158

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 159

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 160

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 161

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 162

Strict Standards: Non-static method t3lib_div::_GP() should not be called statically in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/index_ts.php on line 163

Deprecated: Non-static method t3lib_div::clientInfo() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 393

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3193

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 396

Deprecated: Non-static method t3lib_div::trimExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_db.php on line 897

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 1451

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 509

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 515

Deprecated: Non-static method t3lib_div::intExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_db.php on line 642

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 518

Deprecated: Non-static method t3lib_div::intInRange() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 216

Warning: Cannot modify header information - headers already sent by (output started at /homepages/u23225/typo3_src-4.0.2/t3lib/config_default.php:390) in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 266

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 984

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 985

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 986

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 987

Deprecated: Non-static method t3lib_div::intExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_db.php on line 642

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 915

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 916

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 917

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 918

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 746

Deprecated: Non-static method t3lib_div::intInRange() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 751

Deprecated: Non-static method t3lib_div::inList() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 780

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 780

Deprecated: Non-static method t3lib_div::md5int() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 782

Deprecated: Non-static method t3lib_div::callUserFunction() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 665

Deprecated: Non-static method t3lib_div::isFirstPartOfStr() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3860

Deprecated: Non-static method t3lib_div::isFirstPartOfStr() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3861

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3881

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 746

Deprecated: Non-static method t3lib_div::intInRange() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 751

Deprecated: Non-static method t3lib_div::inList() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 780

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 780

Deprecated: Non-static method t3lib_div::md5int() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 782

Deprecated: Non-static method t3lib_div::callUserFunction() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 665

Deprecated: Non-static method t3lib_div::isFirstPartOfStr() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3860

Deprecated: Non-static method t3lib_div::isFirstPartOfStr() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3861

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3881

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 533

Deprecated: Non-static method t3lib_div::_GP() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 3600

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 620

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3132

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3114

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3110

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3114

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3132

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3125

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3120

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3110

Deprecated: Non-static method t3lib_div::dirname() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3120

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3120

Deprecated: Non-static method t3lib_div::revExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 1033

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 641

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 821

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 984

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 985

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 986

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_userauth.php on line 987

Deprecated: Non-static method t3lib_div::intExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_db.php on line 642

Deprecated: Non-static method t3lib_div::makeInstanceService() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_feuserauth.php on line 166

Deprecated: Non-static method t3lib_div::trimExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 4016

Deprecated: Non-static method t3lib_extMgm::findService() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 4018

Deprecated: Non-static method t3lib_div::getFileAbsFileName() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 4028

Deprecated: Non-static method t3lib_div::isAbsPath() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3325

Deprecated: Non-static method t3lib_div::isFirstPartOfStr() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3327

Deprecated: Non-static method t3lib_div::validPathStr() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 3330

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 4031

Deprecated: Non-static method t3lib_div::makeInstanceService() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_feuserauth.php on line 166

Deprecated: Non-static method t3lib_div::trimExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 4016

Deprecated: Non-static method t3lib_extMgm::findService() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 4018

Deprecated: Non-static method t3lib_div::intExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_page.php on line 1009

Deprecated: Non-static method t3lib_div::testInt() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 1377

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 1246

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 1246

Deprecated: Non-static method t3lib_div::getIndpEnv() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 1246

Deprecated: Function ereg_replace() is deprecated in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_page.php on line 473

Deprecated: Function ereg_replace() is deprecated in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_page.php on line 475

Deprecated: Function ereg_replace() is deprecated in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_page.php on line 478

Deprecated: Non-static method t3lib_div::uniqueList() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_page.php on line 522

Deprecated: Non-static method t3lib_div::trimExplode() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 984

Deprecated: Non-static method t3lib_div::_GET() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 1526

Deprecated: Non-static method t3lib_div::stripSlashesOnArray() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_div.php on line 283

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/typo3/sysext/cms/tslib/class.tslib_fe.php on line 1581

Deprecated: Non-static method t3lib_div::md5int() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_tstemplate.php on line 250

Deprecated: Non-static method t3lib_div::makeInstance() should not be called statically, assuming $this from incompatible context in /homepages/u23225/typo3_src-4.0.2/t3lib/class.t3lib_tstemplate.php on line 269

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Glucosinolate und Krebs
 
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 GeschichteKrebsentstehungFlavonoide und KrebsGlucosinolate und KrebsRelevante Literatur

 

Glucosinolate und Krebs


Glucosinolate sind schwefelhaltige Moleküle, die in den Pflanzen aus Aminosäuren aufgebaut werden. Sie bewirken den typischen, auch scharfen Geschmack, der für Senf, Kresse, Meerrettich und die Kohlgemüse typisch ist.

 

In bestimmten Pflanzenteilen der Kohlgemüse und anderer Kreuzblütler können Glucosinolat-Gehalte von bis zu 3 % gemessen werden. Höchste Gehalte werden üblicherweise in jungen Keimlingen gefunden.

 

Glucosinolate haben eine gemeinsame Grundstruktur, die aus einer Glucoseeinheit, einer schwefelhaltigen Gruppierung mit einem Aglukonrest und einer Sulfatgruppe besteht.  Die über 160 verschiedenen Glucosinolate, die mittlerweile bekannt sind, unterscheiden sich jeweils nur in ihrem Aglukonrest. 

Besonders viele Studien sind mit dem Glucosinolat Glucoraphanin und dem dazugehörigen Isothiocyanat Sulforaphan durchgeführt worden.

 

Grundlegende Arbeiten wurden vor allem an der renommierten John-Hopkins University, Baltimore, MD USA seit Beginn der 90-iger Jahre des letzten Jahrhunderts durchgeführt.

 

Nachfolgende Auflistung versucht nur, einen allgemein verständlichen Überblick über die Glucosinolat/Sulforaphan-Schutzwirkung aus Kohl bei bestimmten Krebsarten zu geben.

 

Als vorweggenommenes Fazit ist zu bemerken, dass der Schutzmechanismus der sekundären Pflanzenstoffe meist auf zwei grundsätzlich gleiche Phänomene zurückzuführen ist:

1. Hemmung Phase-I Enzyme ("Karzinogen-Enzyme") bei gleichzeitigem Anstieg der Phase II-Enzyme ("Entgiftungsenzyme") verhindert die Krebsentstehung in den Frühstadien.

2. Herbeiführen des programmierten Zelltodes (Apoptose) der bereits entstandenen Krebszellen bedeutet Schutzwirkung in späteren Stadien.

 


Prostatakrebs

Die (Indoly)lglucosinolate besitzen stimulierende und regulierende Wirkungen auf den Testosteron- und Östrogenmetabolismus bei Frauen und Männern. Ein Testosteronmangel hemmt die Prostatasekretion, was zu einer Vergrößerung der Prostata (benigne Prostata Hyperplasie=BPH) führt.

Kohl enthält ein wirksames Mittel gegen pathologisch erhöhte PSA-Werte (PSA=prostata spezifische Antigen).

Prostatakrebs ist charakterisiert durch einen frühen und nahezu unumkehrbaren Verlust der Produktion (Expression) des Phase II Enzyms Glutathione Transferase (GST)-pi. Weil also Prostatakrebs mit diesem Verlust einhergeht, scheint eine Enzyminduktion durch Sulforaphan eine mechanistische, simple, Krebs-Präventions-Strategie zu sein.

Phase II-Enzyme werden durch Sulforaphan verstärkt gebildet. Es kommt zu einer Verdopplung oder Verdreifachung bestimmter Phase II-Enzyme.
Quelle:
Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphan. Cancer Epidemiol. Biomarkers Prev.10: 949-954 2001

 

 


Magenkrebs und Helicobacter

Helicobacter-Infektionen des Magens sind ein weltweites Problem. Speziell in Entwicklungsländern stellen sie ein Problem dar und sind häufig mit einem hohen Auftreten von Magenkrebs verbunden. Sulforaphan ist toxisch für Helicobacter. Sogar Helicobacter-Stämme, die resistent gegen herkömmliche Antibiotika geworden sind, werden durch Sulforaphan abgetötet. Ab einer Konzentration von etwa 4 microgramm/ml konnte Helicobacter erfolgreich bekämpft werden.

Chemisch hervorgerufener Magenkrebs wurde ebenfalls durch Sulforaphan positiv beeinflusst. Durch Benzopyren ausgelöster Magenkrebsraten wurden etwa um 40 % reduziert. Hierzu wurden 7,5 micromol Sulforaphan an die Versuchstiere verfüttert.

Quelle:Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewsky A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo(a)pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. USA, 99: 7610-7615 2002

 

 

 

 


Darmkrebs


Eine erfolgreiche Chemoprävention durch die Isothiocyanate Sulforaphan und Phenylethyl isothiocyanat (PEITC) wurde an einem Rattenmodell gezeigt. Chemisch hervorgerufene Tumore wurden erfolgreich durch die Pflanzeninhaltsstoffe reduziert. Die Reduktion erreichte knapp 50 %.

Quelle: Chung F-L, Conaway CC, Rao CV, Reddy BS. Chemoprevention of colonic aberrant foci in Fisher rats by sulforaphane and phenetyl isothiocyanate. Carcinogenesis 21: 2287-2291 2000

 

 

 

 


Brustkrebs


In Tiermodellen konnte die Schutzwirkung von Sulforaphan, dem Abbauprodukt des Glucosinolates Glucoraphanin klar demonstriert werden. In Ratten wurde Brustkrebs chemisch induziert. Während eines Zeitraumes von 5 Tagen die Versuchstiere mit Sulforaphan gefüttert. Während in der Kontrollgruppe ohne Sulforaphan 68 % aller Ratten Krebs entwickelten (=100 %) , waren es in den Gruppen, die oral Sulforaphan bekommen hatten, nur 35 % (=51,4 % der Kontrolle)  bzw. 26,3 % (=38,7 % bezogen auf die Kontrolle).

Diese Experiment zeigen zudem, dass es hier eine Dosisabhängigkeit gibt. Die erfolgreiche  Chemoprävention des Krebses setzt voraus, dass mindestens 75 micromol Sulforaphan eingesetzt werden müssen.

Quelle: Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic nor-bornyl isothiocyanates. Proc. Natl. Acad. Sci. USA, 91: 3147–3150 1994

 


Hautkrebs

Die Arbeitsgruppe um Paul Talalay hat vor wenigen Monaten (siehe auch Aktuelles) ihre Arbeit über die Schutzwirkung von Pflanzenextrakten mit Sulforaphan gegen Hautkrebs veröffentlicht. Auch in diesem Fall, bei einer nun äußerlichen Anwendung von Sulforaphan auf die Haut, scheint ein identischer Wirkmechanismus abzulaufen. Es kommt zu einem verstärkten Anschalten der Phase II-Enzyme (Entgiftungsenzyme). An Mäusen konnte gezeigt werden, dass die Krebsrate durch Sulforaphan halbiert werden konnte.




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